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KMID : 1123920080220030660
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Korean Journal of Oriental Physiology and Pathology
2008 Volume.22 No. 3 p.660 ~ p.665
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Anti-allergic Effect of Bopyeoyangyeong-jun
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Kim Hong-Gi
Lee Jae-Hyuk
Park Sung-Jun
Kim Jin-Young
Kim Bum-Hoi
Park Dong-Il
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Abstract
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In the present study, we investigated the anti-allergic effect of the water extract of Bopyeoyangyeong-jun(BYJ). To investigate the biological effect of BYJ, We examined cytotoxicity and inflammatory cytokine secretion with RBL-2H3. We examined Cell Viability, -hexosaminidase, tumor necrosis factor-alpha(TNF-), interleukin(IL)-4 secretion from RBL-2H3 cell after pre- treatment with Bopyeoyangyeong-jun of 1 mg/ml, 2 mg/ml. RBL-2H3 cell was stimulated with phorbol 12-myristate 13-acetate(PMA) and calcium ionophore A23187. BYJ by itself had no effect on viability of RBL-2H3 cell. We observed that Bopyeoyangyeong-jun reduced -hexosaminidase, TNF-, IL-4 secretion in RBL-2H3 cell. Taken together, these results indicate that Bopyeoyangyeong-jun has anti-histamic effect and controls TNF-, IL-4 secretion on allergic reaction.
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KEYWORD
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Bopyeoyangyeong-junβ-hexosaminidase, TNF-α, IL-4
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